NGS: alignment and sequence variations

What are sequence variations?

Biological sequence variation refers to the differences in DNA sequences between individual organisms within a species. These differences can be due to mutations, which can arise spontaneously or be induced by environmental factors such as exposure to radiation or chemicals. These sequence variations can result in differences in the characteristics of an organism, such as its physical appearance, susceptibility to disease, or response to medications. The study of biological sequence variation is important for a variety of fields, including evolutionary biology, population genomics, and medical genomics.

What Are the Learning Outcomes of This Week?

By the end of this week, you should:

  • Get familiar with the different types of sequence variations

  • Learn how to perform sequence alignment and identification of sequence variants

  • Learn how to visualize the results with the Integrated Genomics Viewer

  • Learn about different types of variation studies

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