# Lipids

Lipids are a diverse group of biological molecules that do not mix with water. The key groups of lipids encompass fats, phospholipids, steroids and waxes. Lipids serve energy storage functions, are the major components of biological membranes, and act as precursors for hormones.

Many lipids can be synthesised by human cells. However, some essential lipids such as omega-3 and omega-6 fatty acids have to be obtained from diet.

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2FfXK0pLvf7uYk6qptWSuy%2FFig_21_lipids_diet.png?alt=media&#x26;token=000a13ae-a181-4cd3-ac55-00c526ebff74" alt="" width="375"><figcaption><p>Some dietary sources of essential lipids</p></figcaption></figure>

## Fats

A typical fat molecule is a **triglyceride** consisting of a **glycerol** part and three **fatty acid** tails. The long fatty acid tails provide fats with their hydrophobic properties.

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2F8Yb0dX2VbGbaTVjAUCQE%2FFig_15_triglyceride.jpeg?alt=media&#x26;token=987712e2-d444-4830-bf2d-f145182271cc" alt=""><figcaption><p>Fats are synthesised by dehydration synthesis<br>Image source:<br>OpenStax College - Anatomy &#x26; Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013., CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=30131156</p></figcaption></figure>

In animals, fats serve as long-term energy storage molecules. Fats are mainly deposited in **adipose tissue** cells that provide thermal insulation and cushion the body's organs.

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2FIuJxUhC45q7wvS0LsYes%2FFig_16_adipose_tissue.jpeg?alt=media&#x26;token=cd83e585-0569-4b33-9def-b74fc75f7da2" alt=""><figcaption><p>Fat is stored in adipose tissue cells<br>Image source:<br>OpenStax College - Anatomy &#x26; Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013., CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=30131287</p></figcaption></figure>

## Phospholipids

Phospholipids are the key components of cell membranes. Phospholipids are structurally similar to fats but only have two fatty acid tails. Instead of the third tail, phospholipids have a negatively charged **phosphate group**. This arrangement results in a dual nature: a strongly hydrophobic part ("tails") that repels water and a hydrophilic part ("head") that attracts water.

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2FQxrDiJ0YmF99MYRcD2hg%2FFig_17_phospholipid.jpeg?alt=media&#x26;token=135ccc7b-b909-4db9-94ba-e63d4fae9d89" alt="" width="255"><figcaption><p>The structure of a phospholipid<br>Image source:<br>OpenStax - https://cnx.org/contents/FPtK1zmh@8.25:fEI3C8Ot@10/Preface, CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=30131167</p></figcaption></figure>

In an aqueous environment, phospholipids tend to form a **bilayer**: the hydrophilic heads face outward, interacting with water, while the hydrophobic tails are concealed within. Phospholipid bilayers comprise the plasma membrane and the internal membranes of eukaryotic cells.

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2F2gLHQGC0zrPKGd7JtgUc%2FFig_18_phospholipid_bilayer.jpeg?alt=media&#x26;token=a30c89c6-60bd-4af1-8152-df2dfe59ce73" alt=""><figcaption><p>Phospholipid bilayer<br>Image source:<br>OpenStax - https://cnx.org/contents/FPtK1zmh@8.25:fEI3C8Ot@10/Preface, CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=30131169</p></figcaption></figure>

## Steroids

Steroids are lipid molecules that have four fused hydrocarbon rings. A  typical steroid is **cholesterol** – the component of animal cell membranes and a precursor of such hormones as estradiol and testosterone.&#x20;

<figure><img src="https://3514673221-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FdDE3NSiCXcu5YQDQmgdU%2Fuploads%2FjWLnNSlWpJ8NtRPrtOIt%2FFig_19_cholesterol.png?alt=media&#x26;token=844a1990-fed9-46cb-9963-cf35462167ae" alt="" width="375"><figcaption><p>Cholesterol</p></figcaption></figure>

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## Summary

The videos below provide the summary of the topic and some additional details:

{% embed url="<https://youtu.be/OpyTJbzA7Fk>" %}

{% embed url="<https://youtu.be/O9lL2KStW9s>" %}

{% embed url="<https://youtu.be/Ezp8F7XJHWE>" %}
